You can use Google AdSense and Amazon Affiliate at the same time. Both programs allow you to monetize your website. You should ensure that your site complies with the policies of both platforms. Google AdSense places ads on your site, while Amazon Affiliate uses product links. You can integrate both without conflicts if you maintain quality content. You should not overload your pages with ads or links. You can place AdSense ads in specific areas and use Amazon links in product-related content. You should focus on providing value to your audience. Using both can maximize your earnings from your website.