WordPress is the best CMS for creating an Amazon affiliate store. You can easily integrate Amazon affiliate links with WordPress. WordPress has many themes and plugins that support affiliate marketing. You can customize your store with drag and drop builders. Shopify is also a good option for building an affiliate store. Shopify offers easy setup but requires more maintenance. You can integrate Amazon products easily with its app. Wix is another CMS that works for affiliate stores but may have fewer options compared to WordPress. Choose WordPress for flexibility and better affiliate integration.